Warfarin Tablet Dosage Guide in Pakistan

Warfarin dose is not fixed like other medicines — it is different for every patient and is adjusted by the doctor based on INR blood test results. Complete dosage guidance is provided below.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

Dosage Guide

Quick Answer

Warfarin dose is highly individual — it is adjusted by your doctor based on regular INR blood test results, not by a fixed mg amount. Typical starting dose is 5mg once daily (lower in elderly/sensitive patients). INR target is 2.0–3.0 for DVT/PE/AF, and 2.5–3.5 for mechanical heart valves. Never self-adjust the dose. Genetic factors (CYP2C9/VKORC1) affect individual response.

Dose at a Glance

Adult Dose

INR-guided — adjusted by doctor; typical starting dose 5mg once daily

Once daily — always at the same time

Max: No fixed maximum — dose is adjusted to achieve the INR target; reversal required for excessive INR

Child Dose (Paediatric use uncommon — specialist only)

Specialist-prescribed only — paediatric haematologist/cardiologist guidance required

As directed

Missed Dose

If a warfarin dose is missed, take it the SAME DAY as soon as you remember. If the next day has already begun, skip that day's dose — NEVER TAKE A DOUBLE DOSE. Always inform your doctor about a missed dose — INR may be affected and dose adjustment may be needed.

Overdose

For warfarin overdose or INR > 5.0, contact a doctor IMMEDIATELY. Signs of over-anticoagulation: unusual or excessive bleeding, black stools, pink/red urine, severe bruising, severe headache. Reversal with Vitamin K1 (phytomenadione) or FFP (Fresh Frozen Plasma) can be done at a hospital emergency department.

Warfarin Tablet Dosage (Kitni leni hai)

Warfarin Tablet dose is not fixed — it is adjusted by the doctor based on INR blood test results. Always follow your doctor's instructions — NEVER change the dose on your own.

Adult Dose (Baalgon ke liye)

Starting dose: Typically 5mg once daily — 2–3mg for elderly patients, those with low body weight, or CYP2C9/VKORC1 sensitive patients
Usual dose: INR-guided — adjusted by doctor; there is no fixed "usual dose"
Max dose: No fixed maximum — dose is reduced when INR > 3.0–4.0; reversal required when INR > 5.0

INR Targets:

Indication	INR Target
DVT / PE	2.0 – 3.0
Atrial Fibrillation (AF)	2.0 – 3.0
Mechanical Heart Valves (standard)	2.5 – 3.5
Antiphospholipid Syndrome	2.5 – 3.5

Child Dose (Bachon ke liye)

Warfarin is uncommon in children — it should only be given under the guidance of a paediatric haematologist or cardiologist specialist. Dosing is weight-based and INR-guided.

How to Take (Kaise leni hai)

Once daily — always at the same time
With or without food — but keep vitamin K intake in the diet consistent
Take the specific colour/strength tablet prescribed by your doctor — confusion between different strengths is dangerous

Best Time to Take (Kab leni chahiye)

Evening — common advice from anticoagulation clinics
Daily same time — for INR stability

With Food or Empty Stomach (Khali pait ya khane ke baad)

Warfarin can be taken with or without food — but avoid sudden changes in the amount of vitamin K rich foods (spinach, broccoli, leafy greens). Consistent diet is essential for INR stability.

Missed Dose (Dose chhoot jaye to kya karein)

If remembered the same day, take it. If the next day has begun, skip it — never take a double dose. Always inform your doctor — a missed dose disrupts the INR and dose adjustment may be needed.

Overdose (Zyada Dose)

For INR > 5.0 or signs of major bleeding, contact a doctor or emergency services IMMEDIATELY. Reversal: Vitamin K1, FFP (Fresh Frozen Plasma) — administered at hospital.

Dose Summary Table

Patient	Approach	INR Target
Adult (DVT/PE/AF)	5mg start, INR-guided	2.0–3.0
Adult (Mechanical Valve)	5mg start, INR-guided	2.5–3.5
Elderly / Sensitive	2–3mg start, careful titration	2.0–3.0
Child	Specialist only	As indicated

The information in this guide is for educational purposes only. Always confirm the dose with your doctor or pharmacist — INR monitoring is mandatory.

Frequently Asked Questions

Warfarin ki dose kitni hoti hai?

Warfarin dose is not fixed — the doctor adjusts it according to the INR blood test. The typical starting dose is 5mg daily. The dose may change over several days until the INR is within the target range.

Warfarin ka INR test kitna zaroori hai?

INR testing is mandatory in warfarin therapy. Initially every 2–3 days, then every 4–8 weeks once stable. The INR target range is 2.0–3.0 — if outside this range, the dose is adjusted.

Warfarin ka missed dose kya karun?

If remembered the same day, take it. If the next day has begun, skip it — never take a double dose. Always inform your doctor because a missed dose disrupts the INR.

Warfarin kitne mg available hai Pakistan mein?

Warf 1mg, 2mg, 3mg, and 5mg tablets are available in Pakistan. The doctor prescribes the exact strength — do not change the strength on your own.

Warfarin ki dose CYP2C9/VKORC1 genetics se kyun affect hoti hai?

In some people the CYP2C9 enzyme metabolizes warfarin slowly, or the VKORC1 gene is sensitive — such patients require a significantly lower dose. A genetics test is available — the doctor assesses this.

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Sources

DRAP Registered Products Database — Drug Regulatory Authority of Pakistan
WHO Model List of Essential Medicines, 23rd ed. (2023) — World Health Organization
British National Formulary (BNF) — BMJ Group & Pharmaceutical Press

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.