Lansoprazole Capsule Side Effects in Pakistan

Lansoprazole side effects — a complete guide. From common effects to serious warnings — everything you need to know is on this page.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

Side Effects

Quick Answer

Common side effects of Lansoprazole include headache, nausea, diarrhoea, and flatulence. Long-term use (over 1 year) carries risks of hypomagnesaemia (muscle cramps, tetany, arrhythmias), Vitamin B12 deficiency, Clostridioides difficile colitis, and increased fracture risk. Lansoprazole also reduces clopidogrel efficacy — cardiac patients should discuss switching to pantoprazole or rabeprazole with their doctor.

Side Effects at a Glance

Common

Headache
Nausea, diarrhoea, constipation, abdominal pain / cramps
Flatulence (gas)
Dizziness
Dry mouth

Serious — See a Doctor

Hypomagnesaemia (long-term use >1 year — muscle cramps, tetany, seizures, cardiac arrhythmias)
Vitamin B12 deficiency (long-term — tingling, fatigue, macrocytic anaemia)
Clostridioides difficile colitis (C. diff — chronic use disrupts gastric acid barrier)
Drug-induced lupus-like reaction (lansoprazole > other PPIs)
Increased fracture risk (hip, wrist, spine — long-term, high-dose)
Interstitial nephritis (rare — kidney inflammation)
Hepatitis (rare)

When to See a Doctor Immediately

Severe watery or bloody diarrhoea
Muscle weakness, cramps, tetany, or irregular heartbeat (hypomagnesaemia)
Tingling hands/feet, extreme fatigue, or macrocytic anaemia signs (Vitamin B12 deficiency)
Severe allergic reaction — rash, swelling, difficulty breathing (anaphylaxis)
Joint pain + rash + fever (drug-induced lupus-like reaction)
Decreased urination or signs of reduced kidney function (interstitial nephritis)

Lansoprazole Capsule Side Effects (Nuksanat)

Lansoprazole Capsule (Zoton, Lanzo) is generally well-tolerated for short-term use. However, in Pakistan this medicine is often used chronically without periodic review — so it is important to be aware of long-term risks.

Common Side Effects (Aam Nuksanat)

Headache
Nausea, diarrhoea, constipation, abdominal pain
Flatulence (gas)
Dizziness
Dry mouth

These side effects are generally mild. If they persist, inform your doctor.

Serious Side Effects (Sanjeedah Nuksanat)

Hypomagnesaemia (long-term use >1 year — muscle cramps, tetany, seizures, cardiac arrhythmias) — see a doctor immediately
Vitamin B12 deficiency (long-term — tingling, fatigue, macrocytic anaemia) — see a doctor immediately
Clostridioides difficile colitis
Drug-induced lupus-like reaction — see a doctor immediately
Increased fracture risk (long-term, high-dose — hip, wrist, spine)
Interstitial nephritis (rare) — see a doctor immediately
Hepatitis (rare) — see a doctor immediately

When to See a Doctor (Kab Doctor Se Milna Zaroori Hai)

Severe watery or bloody diarrhoea (C. diff colitis)
Muscle weakness, cramps, tetany, or irregular heartbeat (hypomagnesaemia)
Tingling hands/feet, extreme fatigue, anaemia (Vitamin B12 deficiency)
Severe allergic reaction — rash, swelling, difficulty breathing
Joint pain + rash + fever (drug-induced lupus-like)
Decreased urination or signs of reduced kidney function (interstitial nephritis)

Warnings and Precautions (Ihtiyat)

Long-term use — have your doctor review the need every 6 months
AVOID with clopidogrel (cardiac patients) — prefer pantoprazole or rabeprazole
Ask your doctor before stopping — rebound acidity may occur
Dose adjustment required in severe liver disease

Side Effects Summary Table

Type	Side Effect	Action
Common	Headache, nausea, diarrhoea	Monitor / inform doctor
Common	Flatulence	Usually resolves
Serious	Hypomagnesaemia (long-term)	See a doctor immediately
Serious	Vitamin B12 deficiency (long-term)	See a doctor immediately
Serious	C. diff colitis	See a doctor immediately
Serious	Drug-induced lupus reaction	See a doctor immediately
Emergency	Severe allergic reaction	Go to emergency room immediately

Reporting Side Effects

If you notice any unexpected side effect, report it on the DRAP pharmacovigilance portal: https://www.dra.gov.pk/pharmacovigilance

The information in this guide is for educational purposes only. If you notice any side effect, contact your doctor or pharmacist.

Frequently Asked Questions

Lansoprazole ke sabse aam side effects kya hain?

The most common effects include headache, nausea, diarrhoea, constipation, and gas. These are generally mild and improve over time. Inform your doctor if they persist.

Kya lansoprazole allergic reaction kar sakti hai?

Yes — if you experience rash, itching, swelling, or difficulty breathing, stop the medicine immediately and see a doctor.

Kya lansoprazole long-term safe hai?

Long-term use is associated with hypomagnesaemia, Vitamin B12 deficiency, C. diff risk, and fracture risk. Your doctor will review the minimum effective dose every 6 months.

Agar lansoprazole se side effects aayein to kya karein?

For mild effects, speak to a pharmacist. For severe effects — bloody diarrhoea, muscle cramps/tetany, tingling, or an allergic reaction — see a doctor or emergency room immediately.

Kya lansoprazole liver ya kidney ko affect karta hai?

Rare hepatitis and interstitial nephritis have been reported. Dose adjustment may be needed in liver or kidney disease — always inform your doctor.

Brand alternatives, same-class options, and other medicines used for the same conditions as Lansoprazole Capsule.

Other ppis and acid reducers

Sibling medicines in the PPIs and Acid Reducers class.

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Used for the same conditions

Other medicines commonly used for cold and flu and overlapping conditions.

Cold and Flu hub →

Sources

DRAP Registered Products Database — Drug Regulatory Authority of Pakistan
WHO Model List of Essential Medicines, 23rd ed. (2023) — World Health Organization
British National Formulary (BNF) — BMJ Group & Pharmaceutical Press

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.