Hilvel Tablet: Uses, Dosage & Side Effects in Pakistan

Hilvel Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

2. What is Hilvel? (Hilvel kya hai)

Hilvel belongs to the hepatitis C direct-acting antiviral (DAA) class and combines two active ingredients, sofosbuvir and velpatasvir, in a single tablet. Sofosbuvir works as a nucleotide analogue that blocks an enzyme the hepatitis C virus needs to copy itself, while velpatasvir targets a different viral protein involved in the same replication process. Together, these two mechanisms interrupt the virus's ability to multiply in the body. Hilvel is prescribed for adults diagnosed with chronic hepatitis C infection, and it is typically used under the ongoing supervision of a hepatologist or infectious-disease specialist rather than a general physician, given the specialised monitoring hepatitis C treatment requires.

Within the hepatitis C DAA class, combination tablets like Hilvel are generally favoured because they pair two complementary antiviral actions in one dose, simplifying the treatment schedule compared to older multi-drug regimens. Treatment with medicines in this class is typically a fixed multi-week course rather than an ongoing daily medicine, with the exact duration decided by the treating specialist based on individual factors. Always take Hilvel as directed by your doctor or pharmacist.

3. Uses (Fayde / Kis kaam aati hai)

• Chronic hepatitis C virus (HCV) infection
• Hepatitis C in patients awaiting or after liver transplantation
• Hepatitis C across multiple genotypes (pangenotypic coverage)

4. Who Should Take (Kis ko leni chahiye)

• Adults diagnosed with chronic hepatitis C infection by a hepatologist or infectious-disease specialist
• Patients advised DAA therapy as part of a liver transplant care plan
• Patients whose treatment plan and genotype have been confirmed through proper testing

5. When NOT to Take (Kab nahi leni chahiye)

• If you are allergic to sofosbuvir, velpatasvir, or any of the ingredients
• If you have a known history of pancreatitis, without specialist clearance
• If you are taking amiodarone, without your doctor's explicit review, due to a risk of slow heart rate

6. Dosage (Kitni leni hai)

• As prescribed

• As prescribed by your treating hepatologist or infectious-disease specialist, typically a fixed multi-week course

• Do not exceed the recommended limit

• If you miss a dose, take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

7. How to Take (Kaise leni hai)

• Once daily

• At the same time each day

• Morning is preferred

• With or without food

8. Best Time (Kab leni chahiye)

• Morning

• Same time daily to maintain a routine and complete the full prescribed course

9. Empty Stomach or After Food (Khali pait ya khane ke baad)

• It can be taken either way — on an empty stomach or after food. Avoid high-fat meals, as they may affect how the medicine is absorbed.

10. Warnings (Ihtiyat)

• Don't use Hilvel if you are allergic to sofosbuvir, velpatasvir, or any ingredient
• Rx — do not take without a doctor's advice; hepatitis C treatment must be supervised by a hepatologist or infectious-disease specialist

11. Precautions (Ahm ehtiyaat)

• Store in a cool, dry place, below 30°C
• Keep away from direct sunlight and moisture
• Keep out of the reach of children

12. Side Effects (Nuksanat)

• Headache, Fatigue, Nausea

• Signs of liver problems (yellowing of skin or eyes, severe stomach pain), Severe allergic reaction (swelling of face, lips, or tongue; difficulty breathing), Slow or irregular heartbeat (especially with amiodarone)

13. Drug Interactions (Dawaon ke sath reaction)

• Amiodarone — risk of a dangerously slow heart rate
• Rifampin, certain anti-seizure medicines (carbamazepine, phenytoin), some anti-diabetic medicines, tipranavir, and warfarin may reduce effectiveness or need closer monitoring

Always share a complete list of your current medicines with your doctor before starting Hilvel, since interactions with this drug class can be serious.

14. When to See Doctor (Kab doctor ke paas jayein)

• Yellowing of the skin or eyes, or severe stomach pain
• Signs of a severe allergic reaction, such as swelling of the face or difficulty breathing
• Unusual heartbeat, extreme fatigue, dizziness, or fainting

15. Alternatives (Sasti Dusri Dawaein)

16. Price in Pakistan (Price kitni hai)

(Note: Price depends on the pharmacy and pack size.)

17. FAQs (Aksar poochay jane walay sawalat)

Q: Hilvel Tablet kis kaam aati hai?

A: Hilvel is prescribed by a doctor for chronic hepatitis C virus infection. See the uses section on PakVita for what it treats and how it is taken as part of a hepatitis C treatment plan.

Q: Kitni mg ki Hilvel Tablet hoti hai?

A: Hilvel is available as a 400mg/100mg (sofosbuvir/velpatasvir) combination tablet. Follow the pack label and your doctor's advice for the exact regimen.

Q: Pakistan mein price kitni hai?

A: The price can vary by pharmacy and city. Verify the current rate at a local store or online listing before purchase.

Q: Pregnancy mein safe hai?

A: Do not self-medicate during pregnancy. Hilvel should only be used in pregnancy if the treating doctor decides the benefit outweighs the risk, always after consultation.

Q: Nuksanat kya hain?

A: Common side effects are usually mild, such as headache and fatigue, but contact your doctor immediately if severe symptoms such as signs of liver problems appear.

18. Medical Review (Medical jaiza)

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-07-02

19. Disclaimer (Zaroori tanbeeh)

The information on this page is for awareness only. It is not medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.