Malanil Tablet Side Effects in Pakistan

A complete guide to the side effects of Malanil Tablet (atovaquone 250mg + proguanil HCl 100mg). From common effects to serious warnings — everything you need to know is on this page.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-07-09

Side Effects

Quick Answer

Common side effects of Malanil Tablet include nausea, abdominal pain, and headache. Serious effects such as anaphylaxis (severe allergic reaction) and hepatitis require immediate medical attention. Most patients tolerate Malanil well at the correct dose. Contact your doctor if any side effect persists or worsens.

Side Effects at a Glance

Common

Nausea
Abdominal pain
Headache
Diarrhoea
Vomiting

Serious — See a Doctor

Severe allergic reaction (anaphylaxis): rash, swelling, difficulty breathing
Hepatitis or elevated liver enzymes
Stevens-Johnson syndrome (severe skin blistering or peeling)

When to See a Doctor Immediately

Jaundice (yellowing of skin or eyes) or dark urine — possible liver toxicity
Severe abdominal pain not resolving with supportive care
Rash with blistering or widespread peeling — possible Stevens-Johnson syndrome
Difficulty breathing, facial swelling, or sudden rash — signs of anaphylaxis

Malanil Tablet Side Effects (Nuksanat)

Malanil Tablet (Atovaquone + Proguanil Hydrochloride) is generally well tolerated when taken at the correct dose with food. However, like all medicines, it can cause side effects in some patients.

Common Side Effects (Aam Nuksanat)

Nausea
Abdominal pain
Headache
Diarrhoea
Vomiting

These side effects are usually mild and improve within a day or two. Taking Malanil Tablet with food or a milky drink reduces nausea. If these symptoms continue, inform your doctor.

Serious Side Effects (Sanjeedah Nuksanat)

Severe allergic reaction (anaphylaxis) — see a doctor immediately
Hepatitis or elevated liver enzymes — see a doctor immediately
Stevens-Johnson syndrome (severe blistering or peeling skin) — seek

emergency care immediately

When to See a Doctor (Kab Doctor Se Milna Zaroori Hai)

Jaundice (yellowing of skin or eyes) or dark urine — stop the medicine and

seek medical attention immediately

Severe abdominal pain that does not improve with supportive measures
Rash with blistering or widespread peeling of skin — possible Stevens-Johnson

syndrome; seek emergency care

Difficulty breathing, facial swelling, or sudden widespread rash — signs of

anaphylaxis; call emergency services

Warnings and Precautions (Ihtiyat)

Do not use Malanil Tablet if you are allergic to atovaquone, proguanil, or

any ingredient in the tablet

Avoid use in severe renal impairment (for prophylaxis) without specialist advice
Rifampicin significantly reduces atovaquone levels — avoid concurrent use
Take with food or a milky drink to improve atovaquone absorption and reduce

gastrointestinal side effects

Side Effects Summary Table

Type	Side Effect	Action
Common	Nausea	Take with food; monitor / inform doctor
Common	Abdominal pain	Take with food; inform doctor if persistent
Common	Headache	Monitor / inform doctor
Common	Diarrhoea	Monitor; ensure hydration
Common	Vomiting	Re-dose if within 1 hour; inform doctor
Serious	Severe allergic reaction (anaphylaxis)	Stop medicine; seek emergency care
Serious	Hepatitis / elevated liver enzymes	Stop medicine; see a doctor immediately
Serious	Stevens-Johnson syndrome	Stop medicine; seek emergency care

Reporting Side Effects

If you notice any unexpected side effect, report it on the DRAP pharmacovigilance portal: https://www.dra.gov.pk/pharmacovigilance

The information in this guide is for educational purposes only. If you notice any side effect, contact your doctor or pharmacist.

Frequently Asked Questions

What are the most common side effects of Malanil Tablet?

The most commonly reported side effects of Malanil Tablet include nausea, abdominal pain, and headache. These are usually mild and go away on their own. Inform your doctor if they persist.

Can Malanil Tablet cause allergic reactions?

Yes, like all medicines, Malanil Tablet can cause allergic reactions in some people. Signs include rash, itching, swelling, or difficulty breathing. Stop use and seek medical help immediately if this happens.

Is Malanil Tablet safe to take for a long time?

Malanil Tablet is generally used for short-term treatment (3 days) or for prophylaxis during travel. Long-term prophylaxis use requires periodic monitoring. Your doctor will advise on safety for your specific duration of use.

What should I do if I experience side effects from Malanil Tablet?

For mild side effects, inform your pharmacist. For serious effects such as anaphylaxis or signs of liver toxicity, stop the medicine and contact your doctor immediately or go to the nearest hospital.

Does Malanil Tablet affect the liver or kidneys?

Malanil Tablet may cause elevated liver enzymes in some patients and is contraindicated in severe renal impairment (creatinine clearance below 30mL/min for prophylaxis). Your doctor will advise based on your test results and overall health condition.

Sources

DRAP Registered Products Database — Drug Regulatory Authority of Pakistan
WHO Model List of Essential Medicines, 23rd ed. (2023) — World Health Organization
British National Formulary (BNF) — BMJ Group & Pharmaceutical Press

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.