Silodosin Capsule: Uses, Dosage & Side Effects in Pakistan

Silodosin Capsule (Urimax / Silodyx) Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

2. What is Silodosin? (Silodosin kya hai)

Silodosin (brand: Urimax, Silodyx) is a highly selective alpha-1A adrenergic receptor blocker. It is used worldwide and in Pakistan for benign prostatic hyperplasia (BPH) — when an enlarged prostate gland presses on the urinary tract, causing difficulty urinating.

Silodosin relaxes the smooth muscle of the prostate and bladder neck — reducing urinary tract resistance and improving flow. It is even more selective for alpha-1A than tamsulosin — theoretically less BP effect — but ejaculatory dysfunction is much more common.

IMPORTANT: Retrograde or absent ejaculation occurs in ~28% of patients with Silodosin — it is reversible but it is ESSENTIAL to inform the patient before starting.

3. Uses (Fayde / Kis kaam aata hai)

• BPH — LUTS: urinary hesitancy, weak stream, frequent urination, waking at night (nocturia), incomplete bladder emptying
• Urgency-frequency syndrome due to BPH — enlarged prostate tightens the bladder neck muscle — silodosin relaxes it

4. Who Should Take (Kin ko di jati hai)

• Adult male patients with a BPH diagnosis and LUTS symptoms
• Doctor's prescription is required

5. When NOT to Take (Kab bilkul nahi leni)

• With strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) — CONTRAINDICATED
• Severe hypotension / low BP
• Severe renal impairment (eGFR < 30 mL/min — avoid; 30–50 mL/min — dose reduce to 4mg)
• Before cataract surgery: stopping the medicine is not mandatory but the ophthalmologist MUST be informed of alpha-blocker use (IFIS risk)
• History of angioedema

6. Dosage (Kitni leni hai)

• 8mg once daily — with a meal
• Elderly patients: start with 4mg OD, monitor, then increase to 8mg

• eGFR 30–50 mL/min: 4mg once daily
• eGFR < 30 mL/min: AVOID

• BPH is an adult male condition — no paediatric use

• Take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

7. How to Take (Kaise leni hai)

• Take with a meal
• Swallow with water — do not open the capsule
• Same time every day — to maintain a routine

8. Best Time (Kab leni chahiye)

• With the evening meal — reduces first-dose hypotension risk
• Or with the morning meal — as per the doctor's advice

9. Empty Stomach or After Food (Khali pait ya khane ke baad)

Take WITH a meal — food reduces silodosin's peak blood level and decreases GI side effects.

10. Warnings (Ihtiyat)

Silodosin causes retrograde or absent ejaculation in ~28% of patients. It is REVERSIBLE but has an impact on quality of life and fertility. It is essential to inform the patient BEFORE starting. If fertility is being planned — consider an alternative.

Every alpha-1 blocker (tamsulosin, alfuzosin, silodosin) can cause IFIS — the iris becomes floppy during cataract surgery. The surgeon MUST be informed of alpha-blocker use — even if it has already been stopped.

BP can drop with the first dose — particularly in elderly patients. Take the first dose at night, and stand up slowly.

Absolutely not with strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin).

11. Precautions (Ahm Ehtiyaat)

• Store below 30°C
• Protect from moisture and direct sunlight
• Keep out of the reach of children

12. Side Effects (Nuksanat)

• Retrograde ejaculation / absent ejaculation
• Dizziness / orthostatic hypotension
• Nasal congestion / rhinitis
• Headache
• Diarrhoea

• Intraoperative Floppy Iris Syndrome (IFIS) — complication during cataract surgery
• Severe orthostatic hypotension — falls / fainting (particularly in elderly)
• Allergic reactions — angioedema, skin rash

13. Drug Interactions (Dawaon ke sath reaction)

• Strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin): silodosin levels rise dramatically — CONTRAINDICATED
• P-gp inhibitors (cyclosporin): levels increase — avoid
• Other alpha-blockers: additive hypotension — avoid combination
• Antihypertensives: additive BP lowering — caution
• PDE5 inhibitors (sildenafil/Viagra, tadalafil/Cialis): additive hypotension — caution at standard doses; consult doctor

14. When to See Doctor (Kab doctor ke paas jayein)

• Severe dizziness or fainting on standing (orthostatic hypotension)
• Urine stops (urinary retention emergency)
• Before cataract surgery — inform the doctor of alpha-blocker use
• Severe allergic reaction
• Dizziness / falls — in elderly (fracture risk)

15. Alternatives (Sasti Dusri Dawaein)

16. Price in Pakistan (Price kitni hai)

17. FAQs (Aksar Poochay Jane Walay Sawalat)

Q: Silodosin kis kaam aata hai?

A: Silodosin is used for urinary difficulty in BPH (enlarged prostate) — frequent urination, hesitancy, weak flow. The muscle of the prostate and bladder neck relaxes.

Q: Silodosin se mard ki tanasul mein masla ho sakta hai?

A: Yes — retrograde or absent ejaculation occurs in ~28% of patients. It is REVERSIBLE — it resolves when the medicine is stopped. However, if fertility is being planned, speak to the doctor first.

Q: Silodosin ke side effects kya hain?

A: The most common is ejaculatory dysfunction (~28%). Dizziness, nasal congestion, and headache can also occur. Inform the ophthalmologist of alpha-blocker use before cataract surgery.

Q: Silodosin price Pakistan mein kya hai?

A: Price varies by pharmacy and pack size. Confirm at a local pharmacy or dawaai.pk.

Q: Silodosin aur tamsulosin mein kya farq hai?

A: Silodosin is more selective for alpha-1A — theoretically less BP effect. But ejaculatory dysfunction is much more common with silodosin (~28% vs ~10–14% with tamsulosin). Tamsulosin is widely available and commonly used in Pakistan. The doctor will decide the best option.

18. Medical Review (Medical Jaiza)

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

19. Disclaimer (Zaroori Tanbeeh)

The information on this page is for awareness only. It is not medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.