Sofohil Tablet: Uses, Dosage & Side Effects in Pakistan

Sofohil Tablet Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

2. What is Sofohil? (Sofohil kya hai)

Sofohil is a brand of sofosbuvir, a medicine that belongs to the direct-acting antiviral (DAA) class used against the hepatitis C virus (HCV). It works by blocking a viral enzyme called NS5B polymerase, which the hepatitis C virus needs to copy its genetic material inside liver cells. By stopping this copying process, sofosbuvir helps lower the amount of virus circulating in the body, allowing the immune system and liver a better chance to recover from infection. It is generally prescribed for adults who have been diagnosed with chronic hepatitis C by a specialist, most often a hepatologist or infectious disease physician who confirms the diagnosis through blood tests before starting therapy.

Within the DAA class, sofosbuvir is typically used as part of a doctor-prescribed combination regimen rather than on its own, since pairing it with another antiviral component is standard practice in modern hepatitis C treatment. The overall approach depends on the patient's viral genotype, liver condition, and prior treatment history, all of which your doctor evaluates individually. Always take Sofohil as directed by your doctor or pharmacist.

3. Uses (Fayde / Kis kaam aati hai)

• Chronic hepatitis C infection, as part of a doctor-prescribed combination antiviral regimen
• Hepatitis C treatment in patients awaiting or after liver transplantation, as directed by a specialist

4. Who Should Take (Kis ko leni chahiye)

• Adults diagnosed with chronic hepatitis C by a hepatologist or infectious disease specialist
• Patients on a doctor-designed combination DAA regimen as part of confirmed HCV treatment
• Patients being managed around liver transplantation under specialist care

5. When NOT to Take (Kab nahi leni chahiye)

• If you are allergic to Sofosbuvir or any of its ingredients
• If you have not been diagnosed and prescribed this medicine by a qualified doctor
• If you are taking rifampin, St. John's Wort, or certain hepatitis C protease inhibitors, without your doctor reviewing your regimen
• During pregnancy or breastfeeding, unless specifically directed by your doctor

6. Dosage (Kitni leni hai)

• As prescribed by your treating specialist

• As prescribed by your doctor, typically as part of a combination regimen with another direct-acting antiviral

• Do not exceed the recommended limit set by your doctor

• If you miss a dose, take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

7. How to Take (Kaise leni hai)

• Once daily, as prescribed

• At the same time each day

• Swallow the tablet with water; do not crush, chew, or break it

• Can be taken with or without food, as advised by your doctor

8. Best Time (Kab leni chahiye)

• The time of day is decided by your doctor as part of your overall treatment plan

• Take it at the same time daily to help maintain a consistent treatment routine

9. Empty Stomach or After Food (Khali pait ya khane ke baad)

• Sofohil can generally be taken either way. Follow your doctor's specific instructions for your regimen.

10. Warnings (Ihtiyat)

• Don't use Sofohil Tablet if you are allergic to Sofosbuvir or any ingredient
• Rx-only — do not start, stop, or continue this medicine without a hepatologist or infectious disease specialist's advice
• Never use as a stand-alone self-treatment; it is normally combined with another direct-acting antiviral as part of a doctor-designed regimen
• Requires liver function monitoring throughout treatment
• Not recommended in pregnancy unless your doctor decides the benefit clearly outweighs the risk

11. Precautions (Ahm ehtiyaat)

• Store in a cool, dry place, below 30°C
• Keep away from direct sunlight and moisture
• Keep out of the reach of children

• Regular liver function tests are typically required during treatment; attend all follow-up appointments

• Sofosbuvir treatment has been associated with fatigue and dizziness in some patients; be cautious with driving or operating machinery until you know how it affects you

12. Side Effects (Nuksanat)

• Fatigue, headache, nausea, insomnia, diarrhea

• Signs of worsening liver function (yellowing of skin/eyes, severe abdominal pain, dark urine), severe allergic reaction (swelling of face/throat, difficulty breathing, severe rash), significant slowing of heart rate (particularly with amiodarone), unusual bleeding or bruising

13. Drug Interactions (Dawaon ke sath reaction)

• Reduced effectiveness when combined with rifampin or St. John's Wort
• Risk of serious slowed heart rate when combined with amiodarone
• Altered blood levels of certain antiretroviral drugs, requiring dose adjustment
• Not recommended together with other hepatitis C protease inhibitors such as telaprevir or boceprevir
• May reduce the effectiveness of hormonal contraceptives — discuss alternative contraception with your doctor

Always share your full medicine list with your doctor before starting Sofohil, since several interactions can affect treatment safety and success.

14. When to See Doctor (Kab doctor ke paas jayein)

• Yellowing of the skin or eyes, dark urine, or severe abdominal pain
• Signs of an allergic reaction, such as facial swelling or difficulty breathing
• Unusually slow or irregular heartbeat, dizziness, or fainting
• Unusual bleeding or bruising
• Any suspected overdose — seek emergency medical help immediately

15. Alternatives (Sasti Dusri Dawaein)

16. Price in Pakistan (Price kitni hai)

(Note: Price depends on the pharmacy and pack size. This is a prescription-only hepatitis C antiviral and requires a valid prescription for purchase.)

17. FAQs (Aksar poochay jane walay sawalat)

Q: Sofohil Tablet kis kaam aati hai?

A: Sofohil Tablet is prescribed by a specialist doctor for chronic hepatitis C infection, usually as part of a combination antiviral regimen. See the uses section on PakVita for more detail.

Q: Kitni mg ki Sofohil Tablet hoti hai?

A: Sofohil Tablet is available in a 400mg strength in Pakistan. The exact regimen and duration are decided by your treating doctor based on your hepatitis C genotype and liver condition.

Q: Pakistan mein price kitni hai?

A: Based on available Pakistani pharmacy listings, a 28-tablet pack is priced at approximately Rs. 5,868 to 5,951. The price can vary by pharmacy, city, and current stock. Verify the current rate before purchase.

Q: Pregnancy mein safe hai?

A: Sofohil Tablet is not recommended during pregnancy unless your doctor decides it is absolutely necessary. Do not self-medicate — always consult your doctor if you are pregnant, breastfeeding, or planning pregnancy.

Q: Nuksanat kya hain?

A: Common side effects are usually mild, such as fatigue, headache, and nausea. Contact your doctor immediately if you notice signs of liver problems, severe allergic reaction, or unusual heart rhythm changes.

18. Medical Review (Medical jaiza)

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-07-02

19. Disclaimer (Zaroori tanbeeh)

The information on this page is for awareness only. It is not medical advice. Sofohil Tablet is a prescription-only hepatitis C antiviral that requires diagnosis, prescription, and monitoring by a qualified doctor. Never self-medicate for hepatitis C. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.