Indapamide Tablet: Uses, Dosage & Side Effects in Pakistan

Indapamide Tablet Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

2. What is Indapamide Tablet? (Indapamide Tablet kya hai)

Indapamide Tablet (Natrilix) is used in Pakistan for high blood pressure (hypertension) and mild fluid retention (oedema). It is a Thiazide-like Diuretic class medicine with Indapamide as the active ingredient. Indapamide blocks the sodium-chloride cotransporter in the renal distal tubule, causing sodium and water to be excreted through urine — this lowers BP. At the low 1.5mg SR dose, the vasodilatory effect predominates — which makes it particularly effective for BP control. The ADVANCE trial showed strong evidence for stroke prevention with the indapamide and perindopril combination.

3. Uses (Fayde / Kis kaam aati hai)

• Hypertension — blood pressure control
• Oedema — mild fluid retention

4. Who Should Take (Kis ko leni chahiye)

• Patients with hypertension (high BP) to whom a doctor has prescribed it
• Patients with mild cardiac oedema
• Patients who do not require the full potency of loop diuretics (furosemide)

5. When NOT to Take (Kab nahi leni chahiye)

• Severe renal impairment (eGFR very low)
• Severe hepatic failure
• Hypokalemia or hyponatraemia
• Proven allergy to sulfonamide or indapamide
• In pregnancy — especially 1st trimester
• During an active gout attack (ask your doctor about the dose)

6. Dosage (Kitni leni hai)

• 1.5mg SR once daily — preferred; or 2.5mg once daily as prescribed

• 1.5mg SR once in the morning; taking it at night may cause nocturnal diuresis and disturb sleep

• 2.5mg per day — a higher dose increases the diuretic effect but does not further improve BP benefit; it causes more electrolyte loss

• If a dose is missed, take it as soon as you remember — but if the next dose time has come, skip it. Never take a double dose. Take the next one at the regular morning time.

7. How to Take (Kaise leni hai)

• Once daily

• Morning preferred

• Same time

• With or without food

8. Best Time (Kab leni chahiye)

• Morning — to avoid nocturnal diuresis

• Same time daily to maintain a routine

9. Empty Stomach or After Food (Khali pait ya khane ke baad)

Indapamide can be taken on an empty stomach or after food — it is not affected by food. However, if nausea occurs, taking it with food is better.

10. Warnings (Ihtiyat)

• Allergy to sulfonamide
• Severe renal or hepatic disease
• Active hypokalemia

• Regular blood tests: potassium, sodium, renal function — especially at the start and after dose changes
• Diabetic patients: monitor blood glucose (mild elevation possible)
• Gout history: check uric acid level

11. Precautions (Ahm ehtiyaat)

• Store in a cool, dry place (below 30°C)
• Keep away from direct sunlight
• Keep out of the reach of children

• Elderly: higher risk of hyponatraemia — monitoring is necessary
• Digoxin users: hypokalemia causes digoxin toxicity — monitor potassium closely
• Diabetics: mild glucose elevation possible — monitor HbA1c

12. Side Effects (Nuksanat)

• Hypokalemia
• Hyponatraemia
• Dizziness / orthostatic hypotension (dizziness on standing suddenly)
• Muscle cramps
• Nausea
• Photosensitivity
• Hyperuricaemia
• Mild hyperglycaemia (blood sugar slightly elevated)

• Severe hypokalemia — cardiac arrhythmia
• Severe hyponatraemia — confusion, seizures
• Hepatic failure
• Sulfonamide hypersensitivity reaction

13. Drug Interactions (Dawaon ke sath reaction)

• Digoxin: hypokalemia increases digoxin toxicity risk — monitor potassium closely
• Lithium: indapamide reduces renal clearance of lithium — lithium toxicity risk
• NSAIDs: antihypertensive effect is reduced
• Antidiabetics: mild glucose elevation — dose adjustment may be needed
• Metformin: lactic acidosis risk with severe dehydration or renal impairment
• QT-prolonging drugs: hypokalemia further prolongs QT interval — dangerous arrhythmia
• Other antihypertensives: additive BP reduction — first-dose hypotension possible

Blood pressure may drop significantly.

14. When to See Doctor (Kab doctor ke paas jayein)

• Severe muscle weakness or cramps — severe hypokalemia
• Confusion, fainting, seizures — severe hyponatraemia (especially elderly)
• Sudden joint pain / swelling — gout attack
• Jaundice, abdominal pain — signs of liver failure
• Severe dizziness or fainting
• Unusually low urine output

15. Alternatives (Sasti Dusri Dawaein)

16. Price in Pakistan (Price kitni hai)

17. FAQs (Aksar poochay jane walay sawalat)

Q: Indapamide kis kaam aata hai?

A: Indapamide (Natrilix) is used for high blood pressure (BP control) and mild oedema in heart failure. It is a thiazide-like diuretic that removes sodium and water through the kidneys and dilates blood vessels.

Q: Indapamide ke side effects kya hain?

A: Common side effects include low potassium (hypokalemia — muscle cramps), dizziness, and nausea. Serious effects: severe hypokalemia causing cardiac arrhythmia (especially in digoxin users) and severe hyponatraemia in the elderly.

Q: Indapamide potassium kyun kam karta hai?

A: Indapamide causes the kidney's distal tubule to excrete potassium along with sodium. This is why regular blood tests to check potassium and supplementation when needed are necessary.

Q: Indapamide price Pakistan mein kitni hai?

A: Natrilix (Servier brand) and local generic indapamide are available in Pakistan. Confirm the latest price at the pharmacy or dawaai.pk.

Q: Indapamide aur furosemide mein farq kya hai?

A: Indapamide is a mild thiazide-like diuretic — better for BP, less potassium loss. Furosemide is a powerful loop diuretic — for severe oedema but more potassium loss. The doctor advises which is needed.

18. Medical Review (Medical jaiza)

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

19. Disclaimer (Zaroori tanbeeh)

The information on this page is for awareness only. It is not medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.