# Letrozole Dosage Guide in Pakistan
The dose of Letrozole is determined by a specialist based on the condition. This guide provides educational information — do not self-prescribe any dose.
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> CRITICAL SAFETY — Pregnancy: > Letrozole is ABSOLUTELY CONTRAINDICATED in pregnancy — it is highly teratogenic and causes serious harm to the fetus. If pregnancy is suspected during treatment, immediately stop the medicine and see a doctor.
> Important Safety Reminder: > Letrozole is a prescription-only medicine. Dose, timing, and duration are determined solely by a specialist. The information provided on this page is for educational purposes only — it is not medical advice.
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Letrozole Ki Dose — Indication Ke Mutabiq
Breast Cancer (Postmenopausal HR+)
| Parameter | Detail |
|---|---|
| Standard Dose (BNF) | 2.5mg once daily |
| Frequency | Once daily, at the same time |
| Duration | Adjuvant: typically 5 years; Extended adjuvant: oncologist decides; Metastatic: as long as beneficial |
| Who Prescribes | Oncologist |
| Monitoring | Regular blood tests, bone density (DEXA scan), cardiovascular assessment |
> Note: 2.5mg daily is the BNF-documented standard dose — however the oncologist decides based on your individual condition, staging, and medical history. This dose information is for educational context, not self-prescription guidance.
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PCOS / Ovulation Induction (Off-Label)
| Parameter | Detail |
|---|---|
| Dose Range | Determined by gynaecologist — typically 2.5mg or 5mg |
| Timing | Typically starting from day 2 or 3 of the menstrual cycle |
| Duration | Usually 5 consecutive days per cycle |
| Who Prescribes | Gynaecologist |
| Monitoring | Transvaginal ultrasound (follicle tracking), hormone levels |
> Important: Letrozole use in PCOS is only under gynaecologist supervision — follicle growth is typically tracked with ultrasound monitoring. Starting any schedule on your own is dangerous.
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Children
Letrozole is not indicated in children. Consult a doctor for any pediatric use.
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Dose Miss Ho Jaye To Kya Karein?
If you forget a dose of Letrozole:
1. Take it as soon as you remember — if there is enough time before the next scheduled dose 2. Skip it — if the time for the next dose is approaching 3. Never double dose — taking two doses at one time can be dangerous 4. Ask your doctor — if unsure, contact your pharmacist or doctor
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Overdose — Kya Karein?
If an accidental overdose is taken:
- Immediately contact a doctor or hospital emergency
- Letrozole overdose can cause serious symptoms
- Poison control helpline or emergency room — immediately
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Long-Term Monitoring (DEXA Scan)
Bone density monitoring is necessary with long-term letrozole use for breast cancer:
- DEXA scan: The doctor recommends checking bone mineral density
- Calcium and Vitamin D: The doctor may prescribe supplements to prevent bone loss
- Regular follow-up: Regular appointments with the oncologist monitor side effects and treatment response
In PCOS treatment, this monitoring is generally not as extensive — the gynaecologist will advise.
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How to Take Letrozole
- Route: Orally — with water
- With or without food: Either way is fine; if stomach discomfort occurs, take it with food
- Same time daily: Building a routine prevents missed doses
- Do not crush/split: Unless specifically instructed by the doctor
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Related Pages
- [Letrozole Uses](/medicines/letrozole-tablet/uses)
- [Letrozole Side Effects](/medicines/letrozole-tablet/side-effects)
- [Letrozole Price in Pakistan](/medicines/letrozole-tablet/price-in-pakistan)
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Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17
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The information on this page is for awareness only. It is not medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.