Trajenta (Linagliptin) Side Effects in Pakistan

Trajenta side effects — a complete guide. From common effects to serious warnings — everything you need to know is on this page. Based on DRAP, WHO, and BNF sources.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

Side Effects

Quick Answer

Common side effects of Trajenta (Linagliptin) include nasopharyngitis (nasal congestion) and upper respiratory infections. Serious but rare effects include acute pancreatitis (severe stomach pain) and bullous pemphigoid (skin blistering). Hypoglycaemia risk increases when combined with sulfonylureas or insulin. Contact your doctor immediately for any serious symptom.

Side Effects at a Glance

Common

Nasopharyngitis (nasal congestion, runny nose)
Upper respiratory tract infection
Hypoglycaemia (low blood sugar) — especially with sulfonylurea or insulin

Serious — See a Doctor

Acute pancreatitis — severe abdominal/stomach pain (rare but life-threatening)
Bullous pemphigoid — skin blistering (class effect of DPP-4 inhibitors, rare)
Severe arthralgia / joint pain (class effect)
Heart failure exacerbation (monitor in at-risk patients)
Anaphylaxis / severe allergic reaction (very rare)

When to See a Doctor Immediately

Severe abdominal pain — may indicate pancreatitis — go to emergency
Skin blisters or peeling rash (jild par phaphole) — stop medicine and see doctor immediately
Loss of consciousness or seizure from severe low blood sugar (hypoglycaemia) — emergency
Swelling of face, lips, tongue, or throat (angioedema — allergic reaction) — emergency
New or worsening shortness of breath — possible heart failure

Trajenta (Linagliptin) Side Effects (Nuksanat)

Trajenta (Linagliptin) is generally well-tolerated at the approved 5mg dose. However, like all medicines, it can cause side effects in some patients.

Common Side Effects (Aam Nuksanat)

Nasopharyngitis (nasal congestion, runny nose)
Upper respiratory tract infection
Hypoglycaemia (low blood sugar) — especially when combined with sulfonylurea or insulin

These side effects are usually mild. If they continue, inform your doctor.

Serious Side Effects (Sanjeedah Nuksanat)

Acute pancreatitis (severe stomach pain — rare) — see a doctor immediately
Bullous pemphigoid (skin blistering — DPP-4 class effect, rare) — see a doctor immediately
Severe joint pain / arthralgia — see a doctor immediately
Heart failure exacerbation — monitor regularly
Anaphylaxis / severe allergic reaction — emergency

When to See a Doctor (Kab Doctor Se Milna Zaroori Hai)

Severe abdominal pain — sign of pancreatitis — emergency
Skin blisters or peeling rash — stop the medicine and see a doctor immediately
Loss of consciousness from low blood sugar — emergency (glucagon needed)
Swelling of face, lips, tongue, throat — allergic reaction — emergency
New or worsening shortness of breath

Warnings and Precautions (Ihtiyat)

Don't use Trajenta if you are allergic to Linagliptin or any ingredient
Avoid Rifampicin combination — drastically reduces Linagliptin levels
Monitor blood sugar more frequently when adding SU or insulin

Side Effects Summary Table

Type	Side Effect	Action
Common	Nasopharyngitis	Monitor / inform doctor
Common	Hypoglycaemia (with SU/insulin)	Monitor blood sugar / inform doctor
Common	URTI	Monitor / inform doctor
Serious	Acute Pancreatitis	See a doctor immediately — emergency
Serious	Bullous Pemphigoid	Stop the medicine, see a doctor immediately

Reporting Side Effects

If you notice any unexpected side effect, report it on the DRAP pharmacovigilance portal: https://www.dra.gov.pk/pharmacovigilance

The information in this guide is for educational purposes only. If you notice any side effect, contact your doctor or pharmacist.

Frequently Asked Questions

Trajenta ke sabse common side effects kya hain?

The most common side effects are nasopharyngitis and upper respiratory tract infections. These are generally mild. There is also a risk of low blood sugar when combined with a sulfonylurea or insulin.

Kya Trajenta se allergic reaction ho sakta hai?

Yes — anaphylaxis or angioedema can occur in rare cases. If these symptoms appear, stop Trajenta and go to the emergency immediately.

Kya Trajenta lambe arse tak safe hai?

Trajenta is generally well-tolerated. Pancreatitis risk should be monitored with long-term use. Continuing under doctor's supervision is safe.

Side effects nazar aayein to kya karein?

For mild side effects (nasal congestion), inform your doctor. For serious symptoms — severe stomach pain, skin blistering, swollen face/throat — stop the medicine and see a doctor immediately or go to the emergency.

Kya Trajenta liver ya kidney ko affect karta hai?

There is no significant negative effect on the kidney — this is one of its advantages. Cautious use and doctor monitoring are required in severe hepatic impairment.

Brand alternatives, same-class options, and other medicines used for the same conditions as Trajenta Tablet (Linagliptin).

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Used for the same conditions

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Sources

DRAP Registered Products Database — Drug Regulatory Authority of Pakistan
WHO Model List of Essential Medicines, 23rd ed. (2023) — World Health Organization
British National Formulary (BNF) — BMJ Group & Pharmaceutical Press

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.