Trajenta Tablet (Linagliptin): Uses, Dosage & Side Effects in Pakistan

Trajenta Tablet (Linagliptin) Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

2. What is Trajenta? (Trajenta kya hai)

Trajenta is a prescription medicine used in Pakistan for the management of Type 2 Diabetes Mellitus. It contains Linagliptin, a member of the DPP-4 Inhibitor (Gliptin) class, manufactured by Boehringer Ingelheim.

Linagliptin works by blocking the DPP-4 enzyme, which normally breaks down the incretin hormones GLP-1 and GIP. When these hormones stay active longer, they stimulate glucose-dependent insulin release from the pancreas and reduce glucagon, lowering blood sugar levels in a meal-linked, glucose-dependent manner.

A key clinical advantage of Trajenta over other gliptins: no dose adjustment is needed in renal impairment, because Linagliptin is excreted mainly via bile and faeces rather than the kidneys. Do not take without doctor's guidance.

3. Uses (Fayde / Kis kaam aati hai)

• Type 2 Diabetes Mellitus — as monotherapy
• Type 2 Diabetes — combination with Metformin, SU, or insulin
• Sugar control in patients with kidney impairment (no dose adjustment needed)

4. Who Should Take (Kis ko leni chahiye)

• Adults diagnosed with Type 2 Diabetes whose blood sugar is not adequately controlled with diet and exercise alone
• Patients who cannot tolerate Metformin or need an additional agent alongside it
• Patients with moderate-to-severe chronic kidney disease (CKD) who need a gliptin — Linagliptin preferred due to renal-safe profile
• Elderly Type 2 Diabetics (use with caution; assess renal/cardiac status first)

5. When NOT to Take (Kab nahi leni chahiye)

• If you are allergic to Linagliptin or any of its ingredients (anaphylaxis/angioedema reported)
• In Type 1 Diabetes Mellitus (insulin-dependent diabetes)
• In diabetic ketoacidosis (DKA — emergency state)
• During pregnancy or breastfeeding without explicit medical advice
• If you have a current active episode of pancreatitis

6. Dosage (Kitni leni hai)

• 5mg once daily — this is also the maintenance dose

• 5mg once daily

• 5mg per day — do not exceed the recommended limit. Higher doses do not provide additional benefit.

• If you miss a dose, take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

7. How to Take (Kaise leni hai)

• Once daily

• Same time to maintain consistent blood levels

• With or without food

• Swallow the tablet whole with water; do not crush unless the doctor has permitted it

8. Best Time (Kab leni chahiye)

• Taking it in the morning is often easier for maintaining a routine

• Daily same time

9. Empty Stomach or After Food (Khali pait ya khane ke baad)

Trajenta can be taken with or without food — both are fine. If the stomach is sensitive on an empty stomach, taking it after food is better.

10. Warnings (Ihtiyat)

• Don't use Trajenta if you are allergic to Linagliptin or any ingredient
• Rifampicin significantly reduces linagliptin levels — avoid this combination
• Risk of low blood sugar when taken with sulfonylurea or insulin — monitor glucose

11. Precautions (Ahm ehtiyaat)

• Store in a cool, dry place — below 30°C
• Keep away from direct sunlight
• Keep out of the reach of children

• Ensure regular blood sugar (HbA1c) monitoring
• If any skin blistering (bullous pemphigoid) appears, inform your doctor immediately
• See a doctor immediately for severe stomach pain to rule out pancreatitis

12. Side Effects (Nuksanat)

• Nasopharyngitis (nasal congestion, runny nose), Hypoglycaemia (with SU/insulin), Upper respiratory tract infection

• Acute pancreatitis (severe stomach pain — rare but serious — see a doctor immediately)
• Bullous pemphigoid (skin blistering — class effect, rare)
• Severe joint pain / arthralgia
• Heart failure exacerbation (monitor in at-risk patients)

13. Drug Interactions (Dawaon ke sath reaction)

• Rifampicin — P-gp/CYP3A4 inducer; significantly reduces Linagliptin levels — avoid this combination
• Sulfonylureas (SU) or Insulin — additive hypoglycaemia risk; SU/insulin dose may need reduction
• ACE Inhibitors (e.g., Enalapril, Ramipril) — increased angioedema risk with combination
• Always consult your pharmacist or doctor before starting or stopping any medicine.

14. When to See Doctor (Kab doctor ke paas jayein)

• Severe abdominal/stomach pain
• Skin blisters (bullous pemphigoid)
• Low blood sugar symptoms: sweating, shaking, confusion — particularly if you cannot treat it yourself
• Signs of allergic reaction: rash, swelling of face/lips/throat, difficulty breathing
• New or worsening shortness of breath (possible heart failure)

15. Alternatives (Sasti Dusri Dawaein)

16. Price in Pakistan (Price kitni hai)

17. FAQs (Aksar poochay jane walay sawalat)

Q: Linagliptin kis kaam aata hai?

A: Trajenta (Linagliptin) is used to control blood sugar in Type 2 Diabetes. It increases insulin release by inhibiting the DPP-4 enzyme. Do not take without a doctor's prescription.

Q: Linagliptin ke side effects kya hain?

A: Common side effects include nasal congestion and respiratory infection. The risk of low blood sugar increases when taken with a sulfonylurea or insulin. See a doctor immediately for skin blistering or severe stomach pain.

Q: Linagliptin kaise lena hai?

A: Take one Trajenta 5mg tablet daily, with or without food — as per your doctor's instructions. Taking it at the same time every day is better for maintaining a routine.

Q: Pakistan mein Trajenta ki price kya hai?

A: The price of Trajenta varies by pharmacy and city. Check the updated price at a local pharmacy or licensed online stores such as dawaai.pk, sehat.com.pk.

Q: Linagliptin kidney patients ke liye safe hai?

A: Yes — one important advantage of Trajenta (Linagliptin) is that dose adjustment is not required in kidney disease. It is mainly eliminated via bile/feces, so it is generally considered safe for CKD patients — however doctor's guidance is essential.

18. Medical Review (Medical jaiza)

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

19. Disclaimer (Zaroori tanbeeh)

The information on this page is for awareness only. It is not medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.