Zestril Tablet (Lisinopril): Uses, Dosage & Side Effects in Pakistan

Zestril Tablet (Lisinopril) Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

2. What is Zestril Tablet? (Zestril Tablet kya hai)

Zestril Tablet contains Lisinopril — it is an ACE Inhibitor (Angiotensin-Converting Enzyme Inhibitor) class medicine. It dilates blood vessels, reducing the load on the heart and controlling blood pressure. In Pakistan it is manufactured by ICI Pakistan.

It is a DRAP-registered prescription medicine for hypertension (high blood pressure), heart failure, post-MI cardioprotection, and kidney protection in diabetes.

3. Uses (Fayde / Kis kaam aati hai)

• Hypertension
• Heart failure
• Post-MI cardioprotection
• Diabetic nephropathy

4. Who Should Take (Kis ko leni chahiye)

• Patients with high blood pressure (hypertension)
• Heart failure patients with reduced ejection fraction
• Those who have experienced a heart attack (MI)
• Diabetic patients who need kidney protection

5. When NOT to Take (Kab nahi leni chahiye)

• Pregnancy — ABSOLUTELY CONTRAINDICATED in 2nd and 3rd trimester — foetal kidneys may be damaged, risk of death
• History of angioedema
• Severe kidney disease (consult doctor again)
• Allergy to any ingredient

6. Dosage (Kitni leni hai)

• As directed by your doctor

• As prescribed by your doctor

• Do not exceed the doctor's prescribed limit

• Take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

7. How to Take (Kaise leni hai)

• Once daily — generally in the morning

• Same time every day — prevents missing a dose

• Can be taken with or without food

8. Best Time (Kab leni chahiye)

• Morning is preferred — most people take it in the morning

• Follow the doctor's instructions

9. Empty Stomach or After Food (Khali pait ya khane ke baad)

Lisinopril is not affected by food — both on an empty stomach and after food are fine. Keep whichever routine suits you — consistency is important.

10. Warnings (Ihtiyat)

• Pregnancy (2nd-3rd trimester) — ABSOLUTELY CONTRAINDICATED
• Previous history of angioedema
• Severe bilateral renal artery stenosis

• Do not take with potassium supplements or potassium-sparing diuretics — risk of hyperkalemia
• Avoid NSAIDs (e.g. Brufen/Ibuprofen) — blood pressure will not reduce adequately + risk of kidney damage

11. Precautions (Ahm ehtiyaat)

• Keep below 30°C in a dry, cool place
• Keep away from direct sunlight
• Keep well out of the reach of children

• Check BP regularly
• Check kidney function (creatinine/BUN) and potassium as advised by the doctor

12. Side Effects (Nuksanat)

• Dry persistent cough — in up to 20% of patients; if intolerable, ask your doctor about switching to an ARB (Losartan/Valsartan)
• Dizziness (chakkar aana)
• Headache (sar dard)
• Fatigue (thakan)
• Hyperkalemia

• Angioedema — swelling of tongue/throat/face — EMERGENCY; stop immediately and go to hospital
• Severe hypotension
• Acute kidney injury
• Fetal toxicity

13. Drug Interactions (Dawaon ke sath reaction)

• NSAIDs (Brufen, Diclofenac, high-dose Aspirin) — reduces antihypertensive effect + risk of kidney damage. May cause blood pressure to drop significantly, which can be dangerous.
• Potassium-sparing diuretics (Spironolactone, Amiloride) and potassium supplements — risk of hyperkalemia
• Lithium — lithium may become toxic; monitor levels
• Antidiabetics (insulin, oral agents) — hypoglycaemia may increase; monitor blood sugar closely

14. When to See Doctor (Kab doctor ke paas jayein)

• Swelling of face, tongue or throat — go to EMERGENCY immediately (angioedema)
• Severe dizziness or fainting
• Muscle weakness or changes in heartbeat
• Reduced urination or swelling of feet
• If pregnancy is detected — see doctor IMMEDIATELY and stop the medicine

15. Alternatives (Sasti Dusri Dawaein)

16. Price in Pakistan (Price kitni hai)

17. FAQs (Aksar poochay jane walay sawalat)

Q: Lisinopril kis kaam aati hai?

A: Lisinopril (Zestril) is used for high blood pressure (hypertension), heart failure, heart protection after MI, and protection of kidneys in diabetes. It is an ACE inhibitor that relaxes blood vessels.

Q: Lisinopril ke side effects kya hain?

A: The most common side effect is a dry, persistent cough occurring in up to 20% of patients. Dizziness, headache and fatigue may also occur. Serious: swelling of face or throat (angioedema) — this is an emergency; go to hospital immediately.

Q: Lisinopril ka istemal kaise karein?

A: Take as per the doctor's prescription — generally once daily, with or without food. Do not increase the dose yourself. When starting with diuretics, a low dose is used initially to prevent dizziness.

Q: Lisinopril price in Pakistan kya hai?

A: Approximate price of Zestril (Lisinopril) in Pakistan is Rs. 120–480 per pack, depending on strength and pack size. Confirm the exact price at your local or online pharmacy — a prescription is required.

Q: Kya Lisinopril safe hai?

A: Generally safe at the correct dose under a doctor's supervision. However, it is absolutely contraindicated in pregnancy. If face or throat swells, stop immediately and go to emergency. Never self-medicate.

18. Medical Review (Medical jaiza)

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17 Last Updated: 2026-06-17

19. Disclaimer (Zaroori tanbeeh)

The information on this page is for awareness only. It is not medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita is not responsible for any harm.