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Osnate-D Tablet: Uses, Dosage & Side Effects in Pakistan

Osnate-D Tablet (Ossein Mineral Complex 830mg + Cholecalciferol (Vitamin D3) 400 IU) ke quick uses, dose guide, side effects, warnings, aur buying price range.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated:

OTC

Form

TABLET

Strength

Ossein Mineral Complex 830mg + Vitamin D3 400 IU

Manufacturer

AGP Limited

Estimated price

Rs. 500 - 550

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What is Osnate-D Tablet used for?

  • Osteoporosis prevention and treatment (bone density support)
  • Calcium and Vitamin D3 deficiency supplementation
  • Post-menopausal bone loss prevention
Read full Uses guide →

How to take Osnate-D Tablet?

Adult dose: 2 tablets twice daily (4 tablets/day) with meals. Each tablet provides approximately 178mg elemental calcium + 400 IU Vitamin D3.

Child dose: Not indicated as a primary supplement for children. Consult a paediatrician for paediatric bone health supplementation.

Read full Dosage guide →

Common side effects

  • Constipation — most common calcium supplement side effect
  • Nausea and mild stomach discomfort
  • Bloating and gas
Read full Side Effects guide →

Important warnings

  • Do not exceed the prescribed dose — risk of hypercalcaemia
  • Avoid in hypercalcaemia, hypercalciuria, or severe renal impairment
  • Calcium can reduce absorption of fluoroquinolone antibiotics, tetracyclines, and bisphosphonates — space doses at least 2 hours apart

Osnate-D Tablet Uses, Dosage, Side Effects & Price in Pakistan

1. Quick Info (Mukhtasir Maloomat)

FieldDetails
Brand NameOsnate-D
Generic NameOssein Mineral Complex 830mg + Cholecalciferol 400 IU
FormTablet
Drug ClassCalcium Supplement + Vitamin D3
ManufacturerAGP Limited
PrescriptionRx — requires a prescription
PriceRs. 500–550 (30 tablets)

2. What is Osnate-D? (Osnate-D kya hai)

Osnate-D is a bone health supplement containing two active ingredients:

1. Ossein Mineral Complex (OMC) 830mg — a natural calcium source derived from bovine bone. Contains calcium and phosphorus in their natural ratio, plus bone matrix proteins (collagen, osteocalcin). Each tablet provides approximately 178mg of elemental calcium. 2. Cholecalciferol (Vitamin D3) 400 IU — the active form of Vitamin D that promotes calcium absorption.

Why Ossein Mineral Complex instead of regular calcium?

FeatureOssein Mineral ComplexCalcium Carbonate
SourceNatural bovine boneMineral/synthetic
Elemental Ca per 830mg~178mg~332mg
Additional componentsCollagen, osteocalcin, phosphorusNone
Stomach toleranceGenerally betterCan cause constipation
BioavailabilityPotentially betterStandard

OMC provides not just calcium, but also the bone matrix proteins that support active bone formation.

3. Uses (Fayde / Kis kaam aati hai)

  • Osteoporosis Prevention — maintaining bone mineral density
  • Osteoporosis Treatment — as a mandatory adjunct to bisphosphonate therapy (alendronate, risedronate)
  • Post-Menopausal Bone Loss — replacing calcium and Vitamin D3 lost after oestrogen decline
  • Steroid-Induced Osteoporosis Prevention — essential for long-term corticosteroid users
  • Calcium and Vitamin D3 Deficiency — for those with low dietary intake or limited sun exposure
  • Pregnancy and Lactation — calcium supplementation under doctor supervision
  • Fall and Fracture Risk Reduction — Vitamin D3 also supports muscle function in the elderly

4. Who Should Take (Kis ko leni chahiye)

  • Post-menopausal women — bone loss prevention
  • Men aged 70 or older — osteoporosis risk
  • Long-term corticosteroid users (prednisone, dexamethasone, etc.)
  • Patients prescribed bisphosphonate therapy for osteoporosis (Osnate-D is a mandatory co-prescription)
  • Women during pregnancy and lactation (doctor prescribed)
  • Patients with low dietary calcium (dairy-free, vegan, low intake)
  • Housebound or low-sun-exposure individuals (Vitamin D deficiency risk)

5. When NOT to Take (Kab nahi leni chahiye)

  • Hypercalcaemia — blood calcium is already elevated
  • Hypercalciuria — excess calcium in urine
  • Severe kidney disease — impaired calcium metabolism
  • History of kidney stones — use with caution and ensure good hydration
  • Sarcoidosis — can cause hypercalcaemia
  • Vitamin D toxicity (hypervitaminosis D)

6. Dosage (Kitni leni hai)

Standard Dosing

IndicationDoseTiming
Osteoporosis treatment or prevention2 tablets twice daily (4 tablets/day)With breakfast and dinner
Calcium deficiency supplement1–2 tablets twice dailyWith meals
Pregnancy or lactationAs doctor prescribesUsually 1–2 tablets daily

Two tablets at each dose provides approximately 356mg elemental calcium + 800 IU Vitamin D3.

Why Split Doses?

Calcium absorption efficiency drops significantly above 500mg per dose. Taking 2 tablets twice daily (rather than 4 at once) means more calcium is actually absorbed.

Critical Timing Rules

  • Bisphosphonates (alendronate): Take on an empty stomach first thing in the morning — then wait 30–60 minutes before eating Osnate-D with breakfast
  • Fluoroquinolone antibiotics (ciprofloxacin, levofloxacin): Take antibiotic 2 hours before, or 4–6 hours after Osnate-D
  • Tetracyclines (doxycycline): Take 2 hours before or 4 hours after Osnate-D
  • Iron supplements: Take 2 hours apart from Osnate-D

7. How to Take (Kaise leni hai)

  • Always take with food — calcium absorption is better with meals
  • Swallow whole with water
  • Split doses (morning and evening) — more effective than one large dose
  • Maintain good fluid intake (2+ litres daily) — reduces kidney stone risk

8. Side Effects (Nuksanat)

Common

  • Constipation — most common calcium supplement side effect; drink more water and increase dietary fibre
  • Nausea — reduced by taking with food
  • Bloating and gas — usually settles over time

Serious (Excessive Dose or Predisposing Conditions)

  • Hypercalcaemia — symptoms include nausea, weakness, confusion, excessive thirst, frequent urination
  • Kidney stones — in predisposed patients; prevented by adequate hydration
  • Vitamin D toxicity — very unlikely at prescribed doses (1600 IU/day from 4 tablets)

9. Drug Interactions (Dawaon ke sath reaction)

MedicineEffectAction
Ciprofloxacin, LevofloxacinAntibiotic absorption blocked2 hrs before OR 4–6 hrs after Osnate-D
Doxycycline, TetracyclineAntibiotic absorption blocked2 hrs before OR 4 hrs after Osnate-D
Alendronate (Fosamax)Bisphosphonate absorption blockedTake bisphosphonate first on empty stomach, Osnate-D with meals
Iron supplementsMutual absorption interferenceTake 2 hours apart
Thiazide diureticsIncreases hypercalcaemia riskMonitor calcium levels
CorticosteroidsReduce calcium absorptionMay need higher dose

10. Storage (Hifazat)

  • Below 30°C, in a dry location
  • Keep in original packaging away from direct sunlight
  • Keep out of reach of children

11. Alternatives in Pakistan

BrandCompositionManufacturer
Osnate-DOMC 830mg + Vit D3 400IUAGP Limited
CalcimaxCalcium + Vit D3Sami Pharma
Bonmax-DCalcium Carbonate + Vit D3Various
Shelcal-HDCalcium Carbonate + Vit D3Various

12. Price in Pakistan (Price kitni hai)

PackPrice (Approx)
Osnate-D (30 tablets)Rs. 500–550

(Prices vary by pharmacy and city)

13. FAQs (Aksar Poochhe Jane Wale Sawalaat)

Q: Should I take separate Vitamin D along with Osnate-D?

A: Osnate-D already provides 400 IU Vitamin D3 per tablet (1600 IU/day from 4 tablets). If your doctor has prescribed additional high-dose Vitamin D, discuss the combined total with them.

Q: Can Osnate-D cause kidney stones?

A: Risk is low if you take the recommended dose and drink plenty of fluids (2+ litres/day). Patients with a prior history of kidney stones should discuss with their doctor before starting.

Q: Can Osnate-D be taken with dairy products?

A: Yes. Dairy provides dietary calcium and Osnate-D supplements any shortfall. The combined daily calcium target from all sources is approximately 1200–1500mg — not more.

14. Disclaimer (Zaroori Tanbeeh)

The information on this page is for awareness only and does not constitute medical advice. Always consult your doctor or pharmacist before taking any medicine. PakVita does not accept liability for any harm arising from use of this information.

Brand alternatives, same-class options, and other medicines used for the same conditions as Osnate-D Tablet.

Frequently Asked Questions

What is Osnate-D Tablet used for?

Osnate-D is a calcium and Vitamin D3 combination supplement used to maintain bone strength and prevent osteoporosis. It is especially important for post-menopausal women and patients taking long-term steroids.

Should Osnate-D be taken with food?

Always take with food — calcium absorption is significantly better with meals, and stomach side effects are reduced.

What is the price of Osnate-D in Pakistan?

Osnate-D (30 tablets) costs approximately Rs. 500–550. It is a prescription supplement manufactured by AGP Limited.

What is Ossein Mineral Complex?

Ossein Mineral Complex is a natural calcium source derived from bovine bone. It contains calcium and phosphorus in their natural ratio, plus bone matrix proteins (collagen, osteocalcin) — which may offer better bioavailability than synthetic calcium carbonate.

Can Osnate-D be taken with antibiotics?

Not at the same time. Calcium blocks absorption of certain antibiotics (ciprofloxacin, doxycycline). Take those antibiotics at least 2 hours before Osnate-D, or 4–6 hours after.

Sources

  1. DRAP Registered Products Database Drug Regulatory Authority of Pakistan
  2. British National Formulary (BNF) — Calcium and Vitamin D BMJ Group & Pharmaceutical Press
  3. International Osteoporosis Foundation — Calcium and Vitamin D International Osteoporosis Foundation

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.