Simvastatin Tablet Dosage Guide in Pakistan

Taking the correct dose of Simvastatin Tablet (Zocor) in the evening or at night is essential for effectiveness. This guide provides complete information on the adult dose, 80mg restriction, drug interaction dose limits, and missed dose guidance.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated: 2026-06-17

Dosage Guide

Quick Answer

Simvastatin Tablet should be taken in the evening or at night as cholesterol synthesis peaks overnight. Usual adult doses are 10mg, 20mg, or 40mg once daily as prescribed. Important: Simvastatin 80mg is RESTRICTED due to high rhabdomyolysis risk — do not use without explicit specialist direction. Always follow your doctor's prescription.

Dose at a Glance

Adult Dose

As prescribed — typically 10mg, 20mg, or 40mg once daily

Once daily in the evening or at night

Max: 40mg daily; 80mg RESTRICTED — do not use

Child Dose (As per specialist's advice)

As prescribed by paediatric cardiologist

As directed by doctor

Missed Dose

If you miss a dose, take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

Overdose

In case of overdose, contact a doctor or emergency room immediately. Simvastatin overdose may cause myopathy or liver damage.

Simvastatin Tablet Dosage (Kitni leni hai)

Taking the correct dose and timing of Simvastatin Tablet (Zocor) is essential for cholesterol management. Always follow your doctor's prescription.

Adult Dose (Baalgon ke liye)

As prescribed — typically 10mg, 20mg, or 40mg once daily
Take in the evening or at night — cholesterol synthesis peaks at night
AVOID 80mg dose — it is restricted; high rhabdomyolysis risk
Do NOT take with grapefruit juice

Starting Dose: As prescribed — commonly 10–20mg at night

Usual Dose: 10–40mg once daily in the evening

Max Daily Dose: 40mg (80mg RESTRICTED — avoid)

Drug Interaction Dose Limits (Important — dose limits by co-medication)

Co-medication	Max Simvastatin Dose
Amiodarone	20mg/day
Amlodipine	20mg/day
Diltiazem	20mg/day
Gemfibrozil	AVOID — do not combine
Strong CYP3A4 inhibitors	CONTRAINDICATED — do not combine

Child Dose (Bachon ke liye)

Under paediatric cardiologist supervision — the dose is decided by the specialist.

A child's dose is always decided by the doctor based on weight and age. Do not calculate the dose yourself.

How to Take (Kaise lena hai)

Once daily in the evening or at night
Can be taken with or without food
Completely avoid grapefruit juice — CYP3A4 inhibition increases simvastatin levels

Best Time to Take (Kab lena chahiye)

In the evening or at night — cholesterol synthesis peaks at night
Daily at the same time — maintain a routine

With Food or Empty Stomach (Khali pait ya khane ke baad)

Can be taken with or without food. Do NOT take with grapefruit juice.

Missed Dose (Dose chhoot jaye to kya karein)

If you miss a dose, take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

Overdose (Zyada Dose)

In case of overdose, contact a doctor or emergency room immediately. Myopathy or liver damage may occur.

Dose Summary Table

Patient	Dose	Notes
Adult	10–40mg once daily (evening/night)	80mg RESTRICTED; check drug interaction limits
Child	Specialist-prescribed	Under paediatric cardiologist supervision

The information in this guide is for educational purposes only. Always confirm the dose with your doctor or pharmacist.

Frequently Asked Questions

Simvastatin Tablet ki standard adult dose kya hai?

Generally 10–40mg once daily in the evening or at night. The dose is as per the doctor's prescription. AVOID 80mg — it is restricted.

Agar Simvastatin Tablet ki dose bhool jaye to kya karein?

Take it as soon as you remember. If the next dose is close, skip the missed dose. Never take a double dose.

Simvastatin raat ko kyun lena chahiye?

Cholesterol synthesis peaks at night. Taking it in the evening or at night allows the drug to overlap more effectively with the liver's cholesterol-making activity.

Amiodarone le raha hun — Simvastatin kitni le sakta hun?

A maximum of 20mg Simvastatin per day is recommended with amiodarone. A higher dose increases the risk of rhabdomyolysis. Confirm with your doctor.

Simvastatin 80mg kyon avoid karein?

The 80mg dose carries a high risk of myopathy and rhabdomyolysis (severe muscle breakdown — kidney failure) and has been restricted by regulators. Only patients already stable on 80mg may continue — new initiation is not permitted.

Brand alternatives, same-class options, and other medicines used for the same conditions as Simvastatin Tablet.

Other statins (cholesterol medicines)

Sibling medicines in the Statins (Cholesterol Medicines) class.

All in class →

Sources

DRAP Registered Products Database — Drug Regulatory Authority of Pakistan
WHO Model List of Essential Medicines, 23rd ed. (2023) — World Health Organization
British National Formulary (BNF) — BMJ Group & Pharmaceutical Press

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.