Simvastatin Tablet side effects
Reported Effects (Nuksanat)
- Myalgia
- Headache
- GI disturbances (nausea, diarrhea, constipation)
Serious Effects and Warning Symptoms (Ahm alamat)
- Myopathy / rhabdomyolysis (severe muscle breakdown — dark urine = kidney emergency)
- Hepatotoxicity (liver damage — jaundice sign)
- New-onset diabetes (class effect — statins)
A list does not determine frequency or prove causation. Seek medical advice for persistent, worsening or unexpected symptoms.
Interactions (Dawaon ke sath reaction)
Itraconazole, ketoconazole, clarithromycin, HIV protease inhibitors — CONTRAINDICATED (rhabdomyolysis); Amiodarone — max 20mg simvastatin; Amlodipine — max 20mg simvastatin; Gemfibrozil — avoid (myopathy); Cyclosporin — avoid; Grapefruit juice — avoid; Warfarin — INR monitoring necessary
Before Changing Treatment (Ilaj badalne se pehle)
- Simvastatin 80mg is RESTRICTED — high myopathy / rhabdomyolysis risk; do NOT use 80mg
- Report unexplained muscle pain or weakness immediately — sign of rhabdomyolysis
- Liver function monitoring is necessary
- Avoid grapefruit juice — CYP3A4 inhibition raises statin levels
- Strong CYP3A4 inhibitors (itraconazole, clarithromycin, HIV protease inhibitors) CONTRAINDICATED — rhabdomyolysis risk
- Max Simvastatin dose with Amiodarone is 20mg
- Max Simvastatin dose with Amlodipine is 20mg
- Avoid with Gemfibrozil — myopathy risk
Related Information (Mazeed maloomat)
Full Simvastatin Tablet guide · Uses · Dosage · Side effects
Educational information only. This editorial correction does not constitute a new clinician review. Confirm the local product leaflet and prescription with a qualified healthcare professional.