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Sofosbuvir (Savera) Dosage Guide in Pakistan

Taking the correct dose of sofosbuvir is essential for HCV treatment success. This medicine is always part of a combination regimen. This guide covers the adult dose, duration, combination examples, and missed dose instructions.

Compiled by the PakVita Editorial Team · AI-assisted drafting with editorial review · Sourced from DRAP, WHO, BNF · Last updated:

Dosage Guide

Quick Answer

Sofosbuvir (Savera) 400mg is taken once daily — always as part of a combination antiviral regimen. The dose and duration depend on the HCV genotype (8 to 24 weeks). Take only on hepatologist's prescription. Do not start or stop the dose on your own.

Dose at a Glance

Adult Dose

400mg (1 tablet) once daily — as part of the combination regimen

Once daily

Max: 400mg per day — do not exceed the prescribed limit

Child Dose (Adult dose for 12 years and above; consult a specialist for younger children)

Paediatric dosing is different — specialist decides based on weight and age

As directed by hepatologist

Missed Dose

If you miss a dose, take it as soon as you remember — if fewer than 12 hours remain until the next dose, skip it. Never take a double dose. Compliance is very important in HCV treatment — missing doses increases the risk of viral resistance.

Overdose

Sofosbuvir overdose can be serious. In case of an overdose, contact a doctor or emergency room immediately. Take the medicine bottle with you.

Sofosbuvir (Savera) Dosage (Kitni leni hai)

Correct use of Savera (Sofosbuvir 400mg) is essential for HCV treatment success. It must always be taken as part of a combination regimen — it is insufficient on its own.

Adult Dose (Baalgon ke Liye)

Standard Dose: 400mg (1 tablet) once daily

Combination Partner: The hepatologist decides based on the genotype.

Duration: Depends on the HCV genotype and liver condition.

Combination Regimens (Doctor Decide Karta Hai)

CombinationDurationHCV Genotype
Sofosbuvir 400mg + Ledipasvir 90mg (Harvoni)8-12 weeks1, 4, 5, 6
Sofosbuvir 400mg + Velpatasvir 100mg (Epclusa)12 weeks1, 2, 3, 4
Sofosbuvir 400mg + Ribavirin12 weeks (genotype 2)2
Sofosbuvir 400mg + Ribavirin24 weeks (genotype 3)3
Sofosbuvir + Velpatasvir + Ribavirin12 weeks (cirrhosis)3 with cirrhosis

These examples are for educational purposes only — your doctor decides for your specific case.

Important: Ye Medicine Khud Start/Band Mat Karein

Sofosbuvir combination therapy is started after HCV genotype testing, liver function tests, and Hepatitis B screening. Stopping mid-course can cause viral resistance or relapse.

Child Dose (Bachon ke Liye)

Use of the Sofosbuvir 400mg adult dose in children under 12 years is documented — the paediatric specialist decides.

The dose in children is always decided by a specialist based on weight and age. Do not calculate the dose on your own.

How to Take (Kaise Lena Hai)

  • Take at the same time every day — make it part of your routine
  • With or without food — both are acceptable
  • Take the combination partner (Ledipasvir/Velpatasvir) at the same time
  • If taking antacids, keep a 4-hour gap from sofosbuvir
  • Swallow the tablet whole — do not crush or chew

Best Time (Kab Lena Chahiye)

  • Morning at the same time — set a phone reminder
  • Maintain a strict daily routine for the long-term course (months)

Missed Dose (Dose Chhoot Jaye to Kya Karein)

If you miss a dose, take it as soon as you remember — if 12 hours or less remain until the next dose, skip it. Never take a double dose.

Compliance in HCV treatment means completing the full course without missing doses — this is the path to cure.

Overdose (Zyada Dose)

In case of overdose, contact a doctor or emergency room immediately. Take the medicine bottle with you.

Dose Summary Table

PatientDoseFrequencyNotes
Adult400mg (1 tablet)Once dailyWith combination
Child (12+)Adult doseOnce dailySpecialist to confirm
Child (<12)Specialist decides—Weight-based

The information in this guide is for educational purposes only. Always confirm the dose with your hepatologist or pharmacist.

Frequently Asked Questions

Sofosbuvir ki dose kya hai?

Sofosbuvir (Savera) 400mg is taken once daily — always with a combination partner. The dose and combination partner are decided by the hepatologist based on the HCV genotype. Setting the dose on your own is not appropriate.

Sofosbuvir kitne hafte lena hota hai?

Duration depends on the HCV genotype and liver condition. Genotype 1: 8-12 weeks with ledipasvir; genotype 2: 12 weeks; genotype 3: 12-24 weeks. Complete the full course as directed by your doctor.

Sofosbuvir khane ke sath ya baghair lein?

Sofosbuvir can be taken with or without food. However, ribavirin should be taken with fatty food — absorption is better.

Kya Sofosbuvir dose miss karna theek hai?

Missing a dose in HCV treatment can be harmful — it carries a risk of viral resistance. If you forget, take it as soon as you remember, but never take a double dose. Set a regular reminder.

Sofosbuvir kitni der mein asar karta hai?

HCV RNA levels generally drop dramatically within 2-4 weeks. An SVR test is done at the end of treatment and 12 weeks after. Do not stop on your own — relapse is possible.

Sources

  1. DRAP Registered Products Database — Drug Regulatory Authority of Pakistan
  2. WHO Model List of Essential Medicines, 23rd ed. (2023) — World Health Organization
  3. British National Formulary (BNF) — BMJ Group & Pharmaceutical Press

Medical disclaimer

This page is for educational use only and does not replace professional medical advice. Always confirm diagnosis, dose, and interactions with a qualified doctor or pharmacist before starting or changing any medicine.